Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes

Singh, Vikash, Pareek, Bhawna, Kinger, Mayank, Sharma, Vivek, Kumar, Sushil (2022). Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes. https://doi.org/10.70130/cast.2022.5208

Singh, Vikash, Pareek, Bhawna, Kinger, Mayank, Sharma, Vivek, Kumar, Sushil. "Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes.". DOI: 10.70130/cast.2022.5208.

Singh, Vikash, Pareek, Bhawna, Kinger, Mayank, Sharma, Vivek, Kumar, Sushil. "Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes.". https://doi.org/10.70130/cast.2022.5208.

@article{singh2022heterocyclic,
  title = {Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes},
  author = {Singh, Vikash and Pareek, Bhawna and Kinger, Mayank and Sharma, Vivek and Kumar, Sushil},
  year = 2022,
  journal = {},
  doi = 10.70130/cast.2022.5208,
  url = oai:ojs2.pubs.rsyn.org:article/150,
  language = en
}

TY  - JOUR
TI  - Heterocyclic Compounds from Dehydroacetic Acid (DHA), and their Metal Complexes
AU  - Singh, Vikash
AU  - Pareek, Bhawna
AU  - Kinger, Mayank
AU  - Sharma, Vivek
AU  - Kumar, Sushil
PY  - 2022
DA  - 2022-11-15
DO  - 10.70130/cast.2022.5208
UR  - oai:ojs2.pubs.rsyn.org:article/150
AB  - This study explores the synthetic versatility and biological relevance of heterocyclic compounds derived from dehydroacetic acid (DHA), a bioactive pyrone derivative. The reactivity of DHA with various nucleophiles—including hydrazines, amines, and Schiff base formers—has been leveraged to synthesize a diverse array of heterocyclic frameworks such as pyranopyrans, isoxazoles, pyranopyrazoles, pyrazolopyridones, benzimidazoles, and pyridones. Furthermore, the formation of metal complexes with these ligands, particularly involving transition metals like Cu(II), Ni(II), Co(II), Mn(II), and Zn(II), has been extensively investigated. These complexes were characterized and evaluated for their antibacterial, antifungal, anticancer, DNA-binding, and DNA-cleaving properties. Notably, Schiff base ligands exhibited enhanced bioactivity upon complexation, suggesting their potential as therapeutic agents. The catalytic potential of these metal complexes was also examined in oxidation, hydrogenation, and polymerization reactions, establishing DHA-based Schiff bases as multifunctional scaffolds in coordination chemistry and biomedical applications.
LA  - en
ER  -